NUCLEAR LAMINA
The Nuclear Lamina is a protein meshwork lining of the inner surface of the nuclear envelope of animal cells and forms the part of the nuclear skeleton network anchoring the chromatin.
It's a structure near the inner nuclear membrane and the peripheral chromatin. It provides mechanical support to the nuclear envelope, serves as a site of attachment for chromatin fibers at the nuclear periphery.
The Nuclear Lamina is involved in various nuclear activities like DNA replication, RNA transcription, nuclear and chromatin organisation, cell cycle regulation, cell development and differentiation, nuclear migration and apoptosis.
The filaments of the nuclear lamina are approximately 10nm in diameter and composed of polypeptides called LAMINS . These are members of the same superfamily of polypeptides that assemble into the 10 nm intermediate filaments of the cytoplasm.The increasing number of proteins that interact with lamins and the compound interaction between these proteins and chromatin associated proteins make the nuclear lamina a highly complex but also a very exciting structure.
The disassembly of the nuclear lamina prior to mitosis is induced by phosphorylation of the lamins.

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